Bleeding and Clotting Time in Different Blood Groups

eject and clotting prison term in Different Blood GroupsComparison of Bleeding Time and clotting Time in different Blood Groups among Medical studentsNadera YasmeenAssistant professor,Department of Physiology, KBNIMS Gulbarga-585104, Karnataka, India abstract entityBackground and objectivesBlood assort, Bleeding quantify and clotting meter be clinically useful tests, extensively used during tune transfusion, platelet disorders and a variety of forms of treatment in hospitals. The objective of our landing field is to find appear if there is any relationship amid the tune hosts with the bleeding beat and clotting prison term in 1st year medical students.Materials and methodsThe arena was performed in 172 apparently healthy 1st year MBBS students in the duration base of 17-20 years, of the department of physiology at KBNIMS, Gulbarga. Bleeding time and clotting time were estimated by Duke Method and capillary tube method respectively. Blood crowding was done with st andard antisera. Finally bleeding time and clotting time of different strain sorts were compared and statistical analysis was done.Results and conclusionThe written report showed that O concourse was found in to a greater extent number of cases (39.5%) than A, B AB line of work meeting. clotting time was increased in blood assembl progressing B than A which was statistically highly monumental. (p 0.05).Keywords Blood Group, Bleeding Time, Clotting Time.INTRODUCTIONBlood grouping is very essential as it plays an significant role in blood transfusion, genetics forensic pathology and it may m another(prenominal) some association with diseases like duodenal ulcer, diabetes mellitus, urinary tract infections, feto-maternal inconsistency leading to haemolytic disease of newborn.1-3Earlier it has been reported that blood group O was over represented in albumen patients admitted with epistaxis compared with the world-wide tweed population.4It is also seen that there is an a ssociation between native Australian blood group perspective and levels of vWF. Blood group O is associated with lower chemical formula of Von von von Willebrand factor ca victimisation a relative bleeding intent 5, 6 ,7 but other workers 8 could not find kayoed any association between the level of vWF and bleeding time.The objective of this knowledge is to find bulge out if there is a relationship between the ABO blood groups with the bleeding time and clotting time in our population.MATERIALS AND METHODSThis study included 172 apparently healthy 1st year MBBS students in the progress group of 17-20 years of the department of Physiology at KBNIMS, Gulbarga, Karnataka, India. Blood groups were determined by mixing the samples of blood with the antisera A, B and D and looking for clumping of RBCs under the microscope. Bleeding time was estimated by Duke Method and clotting time by Capillary tube method respectively9. Prior to the study ethical committee approval was taken fr om college authorities.RESULTSStatistical analysis was done using SPSS package version 19.0. During the study it was found that most of the students belonged to O group 39.5% than A 25.5%, B 28.4% and AB 6.3% and Clotting time was statistically significant in all the blood groups. Bleeding time remained non-significant. Table 1.Table 1 Distribution of blood groups (n = 172)*PGraph 1. Comparison of clotting time Graph 2. Comparison of bleeding time in different blood groups in different blood groupsDISCUSSIONConsiderable research has been carried out all over the world regarding diseases and their correlation with blood group. Reddy et al 4 found in their study that among Caucasian epistaxis patients 50.4% of patients were blood group O but among control groups, this was 45.10%.Another study performed by Daniel et al 8 pointed out that admission for epistaxis was more common among Caucasian than Asian people. Morant AE 5 showed in their study the prevalence of blood group O was more among Caucasians than Asians. (Caucasians 46 versus Asian 31%.) It is seen that persons having any other blood group except O are at more encounter of venous thromboembolism. Non O group individuals have higher levels of von Willebrand factor (vWF) and factor VIII (FVIII) 10, 11.In our study population also, O group was prevalent in more number (39.5%) of cases than other blood group (B- 28.4, A- 25.5, AB- 6.3%). Clotting time was increased in blood group B than A which was statistically highly significant. (pConclusionOur study suggests that O blood group is prevalent in more number of students. Clotting time is more in all the blood groups which was statistically significant. Bleeding time did not show any statistically significant change. throw out larger study is needed to verify the above mentioned conclusions. Further study needs to find out if there is any association of this finding in cases of epistaxis in our population.REFERENCES1. Akhtar MN, Tayyib A, Tasneem T, Butt AR. ABO blood group in patients with peptic ulcer disease Association with secretor status . Ann King Edward Med Coll 2003 9 238-40.2. Qureshi MA, Bhatti R. Frequency of ABO blood groups among the diabetes mellitus type 2 patients. J Coll Physicians Surg Pak 2003 13 453-5.3. Ziegler T, Jacobsohn N, Fnfstck R. Correlation between blood group phenotype and virulence properties of Escherichia coli in patients with chronic urinary tract infection Int. J Antimicrob Agents. 2004 24 Suppl 1570-5.4. Reddy, V.M., M Daniel, E. Bright, S.R. Broad and A.A. Moir, 2008. Is there an association between blood group O and epistaxis ? J. Laryngol. Otol., 122 366-368. DOI 10.1017/S00222151070085605. Mourant, A.E., 1983. Blood transaction Blood Groups and Anthropology. Oxford University Press, New York, pp 146.6. Favaloro, E.J., S. Soltani, J. McDonald, E. Grezchnik, I.. Easton and J. W. Favaloro, 2005. Reassessment of ABO blood group, sex and age on laboratory parameters used to diagnose Von Willeb rand disorder emf influence on the diagnosis Vs the potential association with risk of thrombosis. Am. J. Clin. Pathol. 124 910-917.7. Gill, J.C., E.J. Brooks, P.J. Bauer, W.J. attach Jr and R.R. Montgomery, 1987. The effect of ABO blood group on the diagnosis of Von Willebrand disease. Blood, 69 1691-16958. Daniel, M., M.C.Jaberoo, R.E. Stead, V.M. Reddy and A.A. Moir, 2006. Is admission for epistaxis more common in Caucasian than in Asian people? Preliminary study. Clin. Otolaryngol. 31 386-389.9. Ghai, C.L., 1999. A school text book of Practical Physiology. 5th Edn. Jaypee Brothers, New Delhi, Haematology, pp 84-101.10. Jenkins PV, ODonnell JS. ABO blood group determines plasma von Willebrand factor levels a biologic persist after all? Transfusion. 2006 46 (10)1836-1844.11. 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